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TCF3


Official Full Name
transcription factor 3
Organism
Homo sapiens
Gene ID
6929
Background
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Synonyms
E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21

Cat.No. Product Name Price
SHW004999 shRNA set against Chicken TCF3 (NM_204486) Inquiry
SHH424832 shRNA set against Human TCF3 (NM_003200.3) Inquiry
SHH424836 shRNA set against Mouse TCF3 (NM_011548.4) Inquiry
SHH424840 shRNA set against Rat TCF3 (NM_001107865.1) Inquiry
SHL062154 shRNA set against Mouse Tcf3(NM_009332.2) Inquiry
SHL062172 shRNA set against Mouse Tcf3(NM_001079822.1) Inquiry
Cat.No. Product Name Price
CDCB166474 Chicken TCF3 ORF Clone (NM_204486) Inquiry
CDCR371145 Rat Tcf3 ORF Clone(NM_001035237.1) Inquiry
CDCS408174 Human TCF3 ORF Clone (BC110580) Inquiry
CDFR004455 Rat Tcf3 cDNA Clone(NM_001035237.1) Inquiry
CDFR014043 Rat Tcf3 cDNA Clone(NM_133524.2) Inquiry
MiUTR1R-07942 TCF3 miRNA 3'UTR clone Inquiry
MiUTR1R-07943 TCF3 miRNA 3'UTR clone Inquiry
MiUTR4H-TG08846 TCF3 miRNA 3'UTR clone Inquiry
CDCH018020 Mouse TCF3 ORF clone(NM_011548.4) Inquiry
CDCH089702 Mouse Tcf3 ORF clone (NM_001079822.1) Inquiry
CDCH089704 Mouse Tcf3 ORF clone (NM_009332.2) Inquiry
CDCR240335 Mouse Tcf3 ORF Clone(NM_001164148.1) Inquiry
CDCR381098 Rat Tcf3 ORF Clone(NM_133524.2) Inquiry
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