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TYMS


Official Full Name
thymidylate synthetase
Organism
Homo sapiens
Gene ID
7298
Background
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Synonyms
TS; TMS; DKCD; HST422

Cat.No. Product Name Price
SHH438436 shRNA set against Mouse TYMS (NM_021288.4) Inquiry
SHH438432 shRNA set against Human TYMS (NM_001071.2) Inquiry
SHH438440 shRNA set against Rat TYMS (NM_019179.1) Inquiry
SHL108748 shRNA set against Rat Tyms(NM_019179.1) Inquiry
SHL108784 shRNA set against Human TYMS(NM_001071.2) Inquiry
SHW015160 shRNA set against Danio rerio TYMS (NM_131760) Inquiry
Cat.No. Product Name Price
CDCB189360 Rabbit TYMS ORF clone (XM_002713438.2) Inquiry
CDCR255045 Mouse Tyms ORF Clone(NM_021288.4) Inquiry
CDFL014536 Mouse Tyms cDNA Clone(NM_021288.4) Inquiry
CDFR011477 Rat Tyms cDNA Clone(NM_019179.1) Inquiry
MiUTR1H-10907 TYMS miRNA 3'UTR clone Inquiry
MiUTR1R-08298 TYMS miRNA 3'UTR clone Inquiry
CDCB176635 Danio rerio TYMS ORF Clone (NM_131760) Inquiry
CDCR378350 Rat Tyms ORF Clone(NM_019179.1) Inquiry
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