Pages
Products

TSC1


Official Full Name
TSC complex subunit 1
Organism
Homo sapiens
Gene ID
7248
Background
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
Synonyms
LAM; TSC

Cat.No. Product Name Price
SHH435892 shRNA set against Human TSC1 (NM_000368.4) Inquiry
SHH435896 shRNA set against Mouse TSC1 (NM_022887.3) Inquiry
SHH435900 shRNA set against Rat TSC1 (NM_021854.1) Inquiry
SHL098292 shRNA set against Rat Tsc1(NM_021854.1) Inquiry
SHL098364 shRNA set against Mouse Tsc1(NM_022887.3) Inquiry
SHW013415 shRNA set against Danio rerio TSC1 (NM_001162426) Inquiry
SHW013416 shRNA set against Danio rerio TSC1 (NM_001162427) Inquiry
Cat.No. Product Name Price
CDCH095756 Mouse Tsc1 ORF clone (NM_022887.3) Inquiry
CDFH020438 Human TSC1 cDNA Clone(NM_001162427.1) Inquiry
CDFH020439 Human TSC1 cDNA Clone(NM_001162426.1) Inquiry
CDFL014361 Mouse Tsc1 cDNA Clone(NM_022887.3) Inquiry
CDFR011790 Rat Tsc1 cDNA Clone(NM_021854.1) Inquiry
MiUTR1M-12208 TSC1 miRNA 3'UTR clone Inquiry
MiUTR1R-08238 TSC1 miRNA 3'UTR clone Inquiry
MiUTR3H-07541 TSC1 miRNA 3'UTR clone Inquiry
CDCB174890 Danio rerio TSC1 ORF Clone (NM_001162426) Inquiry
CDCB174891 Danio rerio TSC1 ORF Clone (NM_001162427) Inquiry
CDCB194400 Rabbit TSC1 ORF clone (XM_002721953.2) Inquiry
CDCH095752 human TSC1 ORF clone (NM_001162426.1) Inquiry
CDCH095754 human TSC1 ORF clone (NM_001162427.1) Inquiry
CDCR378848 Rat Tsc1 ORF Clone(NM_021854.1) Inquiry
CDCS405614 Human TSC1 ORF Clone (BC047772) Inquiry
Quick Inquiry