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TPMT


Official Full Name
thiopurine S-methyltransferase
Organism
Homo sapiens
Gene ID
7172
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Synonyms
TPMTD

Cat.No. Product Name Price
SHH433364 shRNA set against Human TPMT (NM_000367.2) Inquiry
SHH433368 shRNA set against Mouse TPMT (NM_016785.2) Inquiry
SHW006576 shRNA set against Danio rerio TPMT.1 (NM_001002569) Inquiry
SHW009284 shRNA set against Danio rerio TPMT.2 (NM_001033586) Inquiry
Cat.No. Product Name Price
CDFH020215 Human TPMT cDNA Clone(NM_000367.2) Inquiry
CDFR005022 Rat Tpmt cDNA Clone(NM_001079531.1) Inquiry
MiUTR1H-10676 TPMT miRNA 3'UTR clone Inquiry
MiUTR1R-03540 TPMT miRNA 3'UTR clone Inquiry
CDCB168051 Danio rerio TPMT.1 ORF Clone (NM_001002569) Inquiry
CDCB170759 Danio rerio TPMT.2 ORF Clone (NM_001033586) Inquiry
CDCB181147 Rabbit TPMT ORF clone (XM_008274110.1) Inquiry
CDCG003550 Mouse TPMT ORF clone(NM_016785.2) Inquiry
CDCR336033 Human TPMT ORF Clone(NM_000367.2) Inquiry
CDCR372096 Rat Tpmt ORF Clone(NM_001079531.1) Inquiry
CDCS405612 Human TPMT ORF Clone (BC005339) Inquiry
CDCS405613 Human TPMT ORF Clone (BC009596) Inquiry
Cat.No. Product Name Price
CC-1458 TPMT Easy KO Kit Inquiry
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