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TP53BP1


Official Full Name
tumor protein p53 binding protein 1
Organism
Homo sapiens
Gene ID
7158
Background
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Synonyms
p202; 53BP1; TDRD30; p53BP1

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CDCB172390 Danio rerio TP53BP1 ORF Clone (NM_001080170) Inquiry
CDCB182991 Rabbit TP53BP1 ORF clone (XM_008269108.1) Inquiry
CDCH094102 human TP53BP1 ORF clone (NM_001141979.1) Inquiry
CDCS408234 Human TP53BP1 ORF Clone (BC112161) Inquiry
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