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TNF


Official Full Name
tumor necrosis factor
Organism
Homo sapiens
Gene ID
7124
Background
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
Synonyms
DIF; TNFA; IMD127; TNFSF2; TNLG1F; TNF-alpha

Cat.No. Product Name Price
SHH431736 shRNA set against Human TNF (NM_000594.3) Inquiry
SHL084132 shRNA set against Mouse Tnf(NM_013693.2) Inquiry
SHH431740 shRNA set against Mouse TNF (NM_013693.2) Inquiry
SHH431744 shRNA set against Rat TNF (NM_012675.3) Inquiry
Cat.No. Product Name Price
CDCS405778 Human TNF ORF Clone (BC028148) Inquiry
CDFL014078 Mouse Tnf cDNA Clone(NM_013693.2) Inquiry
CDFR010491 Rat Tnf cDNA Clone(NM_012675.3) Inquiry
MiUTR1M-11981 TNF miRNA 3'UTR clone Inquiry
MiUTR3H-02321 TNF miRNA 3'UTR clone Inquiry
CDCB156744 Ferret TNF ORF clone (EF368211.1) Inquiry
CDCB156929 Cynomolgus TNF ORF clone Inquiry
CDCB156951 Canine TNF ORF clone (NM_001003244.4) Inquiry
CDCB180215 Rabbit TNF ORF clone (XM_008262537.1) Inquiry
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