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TMED10

Official Full Name
transmembrane p24 trafficking protein 10
Organism
Homo sapiens
GeneID
10972
Background
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Synonyms
p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA);

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