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TIAM1


Official Full Name
TIAM Rac1 associated GEF 1
Organism
Homo sapiens
Gene ID
7074
Background
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Synonyms
NEDLDS; TIAM-1

Cat.No. Product Name Price
SHH427208 shRNA set against Human Tiam1 (NM_003253.2) Inquiry
SHH427212 shRNA set against Mouse Tiam1 (NM_009384.3) Inquiry
SHH427216 shRNA set against Rat Tiam1 (NM_001100558.1) Inquiry
Cat.No. Product Name Price
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CDFL013753 Mouse Tiam1 cDNA Clone(NM_009384.3) Inquiry
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CDCB194606 Rabbit TIAM1 ORF clone (XM_002716805.2) Inquiry
CDCH091020 human TIAM1 ORF clone (NM_003253.2) Inquiry
CDCH091024 Mouse Tiam1 ORF clone (NM_001145886.1) Inquiry
CDCH091026 Mouse Tiam1 ORF clone (NM_001145887.1) Inquiry
CDCR247130 Mouse Tiam1 ORF Clone(NM_009384.3) Inquiry
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