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SLC8A1


Official Full Name
solute carrier family 8 member A1
Organism
Homo sapiens
Gene ID
6546
Background
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Synonyms
NCX1

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Cat.No. Product Name Price
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CDFH018041 Human SLC8A1 cDNA Clone(NM_001112802.1) Inquiry
CDFH018040 Human SLC8A1 cDNA Clone(NM_001112800.1) Inquiry
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MiUTR1H-09601 SLC8A1 miRNA 3'UTR clone Inquiry
CDCR382719 Mouse Slc8a1 ORF Clone(NM_001112798.1) Inquiry
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CDCH082982 human SLC8A1 ORF clone (NM_001252624.1) Inquiry
CDCH082980 human SLC8A1 ORF clone (NM_001112802.1) Inquiry
CDCH082978 human SLC8A1 ORF clone (NM_001112801.1) Inquiry
CDCB180266 Rabbit SLC8A1 ORF clone (NM_001170958.1) Inquiry
CDCH401210 Human SLC8A1 ORF clone(NM_021097.2) Inquiry
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