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SHC1


Official Full Name
SHC adaptor protein 1
Organism
Homo sapiens
Gene ID
6464
Background
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Synonyms
SHC; SHCA

Cat.No. Product Name Price
SHH406964 shRNA set against Human SHC1 (NM_003029.4) Inquiry
SHH406968 shRNA set against Mouse SHC1 (NM_011368.5) Inquiry
SHH406972 shRNA set against Rat SHC1 (NM_053517.2) Inquiry
SHR224016 shRNA set against Human SHC1(NM_183001.4) Inquiry
SHW004511 shRNA set against Chicken SHC1 (NM_001293280) Inquiry
Cat.No. Product Name Price
SKO0238 SHC1 Validated sgRNA vector Inquiry
MiUTR1H-09376 SHC1 miRNA 3'UTR clone Inquiry
MiUTR1H-09375 SHC1 miRNA 3'UTR clone Inquiry
MiUTR1H-09374 SHC1 miRNA 3'UTR clone Inquiry
CDFR013243 Rat Shc1 cDNA Clone(NM_053517.2) Inquiry
CDFH017508 Human SHC1 cDNA Clone(NM_001130040.1) Inquiry
CDFH017507 Human SHC1 cDNA Clone(NM_001130041.1) Inquiry
CDFG019173 Mouse Shc1 cDNA Clone(NM_001113331.2) Inquiry
MiUTR3H-03476 SHC1 miRNA 3'UTR clone Inquiry
CDCS407897 Human SHC1 ORF Clone (BC014158) Inquiry
CDCR380160 Rat Shc1 ORF Clone(NM_053517.2) Inquiry
CDCH400371 Rat Shc1 ORF clone(NM_001164060.1) Inquiry
CDCH079956 Mouse Shc1 ORF clone (NM_001113331.2) Inquiry
CDCH079948 human SHC1 ORF clone (NM_001202859.1) Inquiry
CDCH079946 human SHC1 ORF clone (NM_183001.4) Inquiry
CDCH079944 human SHC1 ORF clone (NM_001130041.1) Inquiry
CDCH079942 human SHC1 ORF clone (NM_001130040.1) Inquiry
CDCB192007 Rabbit SHC1 ORF clone (XM_008264366.1) Inquiry
CDCR250597 Mouse Shc1 ORF Clone(NM_011368.5) Inquiry
CDCB165986 Chicken SHC1 ORF Clone (NM_001293280) Inquiry
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