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SHANK3


Official Full Name
SH3 and multiple ankyrin repeat domains 3
Organism
Homo sapiens
Gene ID
85358
Background
This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
Synonyms
PSAP2; SCZD15; PROSAP2; SPANK-2; DEL22q13.3

Cat.No. Product Name Price
AD14622Z Human SHANK3 adenoviral particles Inquiry
Cat.No. Product Name Price
SHH406928 shRNA set against Mouse SHANK3 (NM_021423.3) Inquiry
SHR223800 shRNA set against Rat Shank3(NM_021676.1) Inquiry
SHH406932 shRNA set against Rat SHANK3 (NM_021676.1) Inquiry
Cat.No. Product Name Price
CDCB189041 Rabbit SHANK3 ORF clone (XM_008252742.1) Inquiry
CDFL012274 Mouse Shank3 cDNA Clone(NM_021423.3) Inquiry
CDFR011725 Rat Shank3 cDNA Clone(NM_021676.1) Inquiry
MiUTR1R-07335 SHANK3 miRNA 3'UTR clone Inquiry
CDCH079918 human SHANK3 ORF clone (NM_033517.1) Inquiry
CDCR255282 Mouse Shank3 ORF Clone(NM_021423.3) Inquiry
CDCR378772 Rat Shank3 ORF Clone(NM_021676.1) Inquiry
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