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SETDB2

Official Full Name
SET domain bifurcated histone lysine methyltransferase 2
Organism
Homo sapiens
GeneID
83852
Background
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Synonyms
CLLD8; CLLL8; KMT1F; C13orf4;

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