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SERPINC1


Official Full Name
serpin family C member 1
Organism
Homo sapiens
Gene ID
462
Background
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]
Synonyms
AT3; AT3D; ATIII; THPH7; ATIII-R2; ATIII-T1; ATIII-T2

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SHH405324 shRNA set against Human SERPINC1 (NM_000488.3) Inquiry
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SHH405332 shRNA set against Rat SERPINC1 (NM_001012027.1) Inquiry
SHR217858 shRNA set against Rat Serpinc1(NM_001012027.1) Inquiry
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Cat.No. Product Name Price
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CDCB177013 Danio rerio SERPINC1 ORF Clone (NM_182863) Inquiry
CDCB184441 Rabbit SERPINC1 ORF clone (XM_002715030.2) Inquiry
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