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ROCK1


Official Full Name
Rho associated coiled-coil containing protein kinase 1
Organism
Homo sapiens
Gene ID
6093
Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Synonyms
ROCK-I; P160ROCK

Cat.No. Product Name Price
SHH397624 shRNA set against Human ROCK1 (NM_005406.2) Inquiry
SHH397628 shRNA set against Mouse ROCK1 (NM_009071.2) Inquiry
SHH397632 shRNA set against Rat ROCK1 (NM_031098.1) Inquiry
SHR189288 shRNA set against Rat Rock1(NM_031098.1) Inquiry
SHR189318 shRNA set against Mouse Rock1(NM_009071.2) Inquiry
SHR189336 shRNA set against Human ROCK1(NM_005406.2) Inquiry
SHW003257 shRNA set against Chicken ROCK1 (NM_001199448) Inquiry
SHW014059 shRNA set against Danio rerio ROCK1 (NM_001256634) Inquiry
Cat.No. Product Name Price
CDFL011641 Mouse Rock1 cDNA Clone(NM_009071.2) Inquiry
CDFR012569 Rat Rock1 cDNA Clone(NM_031098.1) Inquiry
MiUTR1H-08917 ROCK1 miRNA 3'UTR clone Inquiry
MiUTR1M-10198 ROCK1 miRNA 3'UTR clone Inquiry
MiUTR1R-07016 ROCK1 miRNA 3'UTR clone Inquiry
SKO0261 ROCK1 Validated sgRNA vector Inquiry
CDCB164732 Chicken ROCK1 ORF Clone (NM_001199448) Inquiry
CDCB175534 Danio rerio ROCK1 ORF Clone (NM_001256634) Inquiry
CDCB180419 Rabbit ROCK1 ORF clone (NM_001082367.1) Inquiry
CDCR379471 Rat Rock1 ORF Clone(NM_031098.1) Inquiry
CDCR382846 Mouse Rock1 ORF Clone(NM_009071.2) Inquiry
CDCS412239 Human ROCK1 ORF Clone (BC113114) Inquiry
Cat.No. Product Name Price
CC-1231 ROCK1 Easy KO Kit Inquiry
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