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RFX5


Official Full Name
regulatory factor X5
Organism
Homo sapiens
Gene ID
5993
Background
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]
Synonyms
MHC2D3; MHC2D5

Cat.No. Product Name Price
SHH392436 shRNA set against Human RFX5 (NM_000449.3) Inquiry
SHH392440 shRNA set against Mouse RFX5 (NM_017395.2) Inquiry
SHH392444 shRNA set against Rat RFX5 (NM_001107694.1) Inquiry
SHR169664 shRNA set against Mouse Rfx5(NM_017395.2) Inquiry
SHR169752 shRNA set against Human RFX5(NM_000449.3) Inquiry
Cat.No. Product Name Price
CDCH073244 Mouse Rfx5 ORF clone (NM_017395.2) Inquiry
CDCR374415 Rat Rfx5 ORF Clone(NM_001107694.1) Inquiry
CDFH016215 Human RFX5 cDNA Clone(NM_000449.3) Inquiry
CDFH016216 Human RFX5 cDNA Clone(NM_001025603.1) Inquiry
CDFL011444 Mouse Rfx5 cDNA Clone(NM_017395.2) Inquiry
CDFR007341 Rat Rfx5 cDNA Clone(NM_001107694.1) Inquiry
MiUTR1H-08764 RFX5 miRNA 3'UTR clone Inquiry
MiUTR1M-10052 RFX5 miRNA 3'UTR clone Inquiry
MiUTR3H-04463 RFX5 miRNA 3'UTR clone Inquiry
SKO1058 RFX5 Validated sgRNA vector Inquiry
CDCB195004 Rabbit RFX5 ORF clone (XM_008264046.1) Inquiry
CDCR336423 Human RFX5 ORF Clone(NM_000449.3) Inquiry
CDCR342572 Human RFX5 ORF Clone(NM_001025603.1) Inquiry
CDCS405669 Human RFX5 ORF Clone (BC017471) Inquiry
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