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RBFOX1


Official Full Name
RNA binding fox-1 homolog 1
Organism
Homo sapiens
Gene ID
54715
Background
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Synonyms
2BP1; FOX1; A2BP1; FOX-1; HRNBP1

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CDFH015992 Human RBFOX1 cDNA Clone(NM_001142333.1) Inquiry
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CDCB183427 Rabbit RBFOX1 ORF clone (XM_008257684.1) Inquiry
CDCR022364 Human RBFOX1 ORF clone (NM_001142333.1) Inquiry
CDCR275935 Mouse Rbfox1 ORF Clone(NM_183188.2) Inquiry
CDCR351187 Human RBFOX1 ORF Clone(NM_001142334.1) Inquiry
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