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RAPGEF5


Official Full Name
Rap guanine nucleotide exchange factor 5
Organism
Homo sapiens
Gene ID
9771
Background
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Synonyms
GFR; MRGEF; REPAC; MR-GEF

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Cat.No. Product Name Price
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