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RPA1


Official Full Name
replication protein A1
Organism
Homo sapiens
Gene ID
6117
Background
This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]
Synonyms
HSSB; RF-A; RP-A; REPA1; RPA70; MST075; PFBMFT6

Cat.No. Product Name Price
SHH397848 shRNA set against Human RPA1 (NM_002945.3) Inquiry
SHH397852 shRNA set against Mouse RPA1 (NM_026653.2) Inquiry
SHH397856 shRNA set against Rat RPA1 (NM_001047843.1) Inquiry
SHW000311 shRNA set against Chicken RPA1 (NM_001006221) Inquiry
SHW016080 shRNA set against Danio rerio RPA1 (NM_199811) Inquiry
Cat.No. Product Name Price
CDFG020591 Mouse Rpa1 cDNA Clone(NM_001164223.1) Inquiry
CDFR004856 Rat Rpa1 cDNA Clone(NM_001047843.1) Inquiry
MiUTR1R-07022 RPA1 miRNA 3'UTR clone Inquiry
MiUTR4H-TG07627 RPA1 miRNA 3'UTR clone Inquiry
CDCB158039 Human RPA1 ORF clone (BC018126) Inquiry
CDCB161786 Chicken RPA1 ORF Clone (NM_001006221) Inquiry
CDCB177555 Danio rerio RPA1 ORF Clone (NM_199811) Inquiry
CDCB192776 Rabbit RPA1 ORF clone (XM_008270927.1) Inquiry
CDCH074986 Mouse Rpa1 ORF clone (NM_001164223.1) Inquiry
CDCR371930 Rat Rpa1 ORF Clone(NM_001047843.1) Inquiry
CDCS411057 Human RPA1 ORF Clone (BC018126) Inquiry
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