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ROBO3


Official Full Name
roundabout guidance receptor 3
Organism
Homo sapiens
Gene ID
64221
Background
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019]
Synonyms
HGPS; RIG1; HGPPS; RBIG1; HGPPS1

Cat.No. Product Name Price
SHH397608 shRNA set against Rat ROBO3 (NM_001108135.1) Inquiry
SHH397600 shRNA set against Human ROBO3 (NM_022370.3) Inquiry
SHW014927 shRNA set against Danio rerio ROBO3 (NM_131482) Inquiry
Cat.No. Product Name Price
CDFR007797 Rat Robo3 cDNA Clone(NM_001108135.1) Inquiry
MiUTR3H-10124 ROBO3 miRNA 3'UTR clone Inquiry
CDCB176402 Danio rerio ROBO3 ORF Clone (NM_131482) Inquiry
CDCB192325 Rabbit ROBO3 ORF clone (XM_002708315.2) Inquiry
CDCR307794 Human ROBO3 ORF Clone(NM_022370.3) Inquiry
CDCR374694 Rat Robo3 ORF Clone(NM_001108135.1) Inquiry
CDCS415494 Human ROBO3 ORF Clone (BC008623) Inquiry
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