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REN


Official Full Name
renin
Organism
Homo sapiens
Gene ID
5972
Background
This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020]
Synonyms
RTD; HNFJ2; ADTKD4

Cat.No. Product Name Price
SHH323843 shRNA set against Human KCTD11 (NM_001002914.2) Inquiry
SHH323847 shRNA set against Mouse KCTD11 (NM_153143.4) Inquiry
SHH323851 shRNA set against Rat KCTD11 (NM_001108831.2) Inquiry
SHH332579 shRNA set against Rat LOC641520 (NM_001037369.1) Inquiry
SHH391892 shRNA set against Human REN (NM_000537.3) Inquiry
SHH391896 shRNA set against Mouse REN (NM_023132.3) Inquiry
SHH391900 shRNA set against Rat REN (NM_012642.4) Inquiry
SHH391904 shRNA set against Mouse Ren1 (NM_031192.3) Inquiry
SHH391908 shRNA set against Mouse Ren2 (NM_031193.2) Inquiry
SHR175920 shRNA set against Rat Ren1(NM_012642.4) Inquiry
SHW018007 shRNA set against Danio rerio REN (NM_212860) Inquiry
Cat.No. Product Name Price
OE-PNDC000376 Human KCTD11 Nanodisc Inquiry
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MiUTR3H-02011 REN miRNA 3'UTR clone Inquiry
MiUTR1R-03506 LOC641520 miRNA 3'UTR clone Inquiry
MiUTR1M-10021 REN2 miRNA 3'UTR clone Inquiry
MiUTR1H-05173 KCTD11 miRNA 3'UTR clone Inquiry
CDFR010460 Rat Ren cDNA Clone(NM_012642.4) Inquiry
CDFR008399 Rat Kctd11 cDNA Clone(NM_001108831.2) Inquiry
CDFR004538 Rat LOC641520 cDNA Clone(NM_001037369.1) Inquiry
MiUTR1R-06374 REN miRNA 3'UTR clone Inquiry
CDCS406161 Human KCTD11 ORF Clone (BC019929) Inquiry
CDCS405730 Human REN ORF Clone (BC047752) Inquiry
CDCR377507 Rat Ren ORF Clone(NM_012642.4) Inquiry
CDCR371578 Rat LOC641520 ORF Clone(NM_001037369.1) Inquiry
CDCR270200 Mouse Kctd11 ORF Clone(NM_153143.4) Inquiry
CDCL185969 Mouse REN1 ORF clone(NM_031193.2) Inquiry
CDCH396697 Mouse Ren1 ORF clone(NM_031192.3) Inquiry
CDCB197001 Rabbit LOC103347116 ORF clone (XM_008253577.1) Inquiry
CDCB190264 Rabbit KCTD11 ORF clone (XM_008270790.1) Inquiry
CDCB182767 Rabbit REN ORF clone (XM_008268541.1) Inquiry
CDCR375454 Rat Kctd11 ORF Clone(NM_001108831.2) Inquiry
CDCB179482 Danio rerio REN ORF Clone (NM_212860) Inquiry
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