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RASSF1

Official Full Name
Ras association (RalGDS/AF-6) domain family member 1
Background
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms
RASSF1; Ras association (RalGDS/AF-6) domain family member 1; ras association domain-containing protein 1; 123F2; NORE2A; RDA32; REH3P21; Ras association domain containing protein 1; Ras association domain family 1; Ras association domain family protein 1; RASF1_HUMAN; RASSF 1a; RASSF1A; RASSF1A isoform; Tumor suppressor protein RDA32; WUGSC:H_LUCA12.5; OTTHUMP00000195503; OTTHUMP00000195504; OTTHUMP00000195505; OTTHUMP00000195507; cardiac-specific ras association domain family 1 protein; pancreas-specific ras associat; pancreas-specific ras association domain family 1 protein; Ras association (RalGDS/AF-6) domain family 1; zgc:92505; wu:fc17f02; zgc:112224

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