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RASA1


Official Full Name
RAS p21 protein activator 1
Organism
Homo sapiens
Gene ID
5921
Background
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
Synonyms
GAP; PKWS; RASA; p120; CMAVM; CM-AVM; CMAVM1; RASGAP; p120GAP; p120RASGAP

Cat.No. Product Name Price
SHH389848 shRNA set against Human RASA1 (NM_002890.2) Inquiry
SHH389852 shRNA set against Mouse RASA1 (NM_145452.3) Inquiry
SHH389856 shRNA set against Rat RASA1 (NM_013135.1) Inquiry
SHH421696 shRNA set against Human SYNGAP1 (NM_006772.2) Inquiry
SHH421704 shRNA set against Rat SYNGAP1 (NM_181092.4) Inquiry
SHR165648 shRNA set against Mouse Rasa1(NM_145452.3) Inquiry
SHR165666 shRNA set against Rat Rasa1(NM_013135.1) Inquiry
Cat.No. Product Name Price
CDCB186578 Rabbit SYNGAP1 ORF clone (XM_002714384.2) Inquiry
MiUTR3H-00958 RASA1 miRNA 3'UTR clone Inquiry
MiUTR3H-00957 RASA1 miRNA 3'UTR clone Inquiry
MiUTR1R-06319 RASA1 miRNA 3'UTR clone Inquiry
MiUTR1M-09933 RASA1 miRNA 3'UTR clone Inquiry
CDFR014942 Rat Syngap1 cDNA Clone(NM_181092.4) Inquiry
CDFR010934 Rat Rasa1 cDNA Clone(NM_013135.1) Inquiry
CDFR009313 Rat Syngap1 cDNA Clone(NM_001113409.2) Inquiry
MiUTR3H-05917 SYNGAP1 miRNA 3'UTR clone Inquiry
CDFH019076 Human SYNGAP1 cDNA Clone(NM_006772.2) Inquiry
CDCH071778 human SYNGAP1 ORF clone (NM_006772.2) Inquiry
SKO0105 RASA1 Validated sgRNA vector Inquiry
CDCR381989 Rat Syngap1 ORF Clone(NM_181092.4) Inquiry
CDCR377981 Rat Rasa1 ORF Clone(NM_013135.1) Inquiry
CDCR376360 Rat Syngap1 ORF Clone(NM_001113409.2) Inquiry
CDCR308011 Human RASA1 ORF Clone(NM_022650.2) Inquiry
CDCH071780 Mouse Rasa1 ORF clone (NM_145452.3) Inquiry
CDCB191683 Rabbit RASA1 ORF clone (XM_008261920.1) Inquiry
CDCS411025 Human RASA1 ORF Clone (BC033015) Inquiry
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