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RAPGEF4

Official Full Name
Rap guanine nucleotide exchange factor 4
Organism
Homo sapiens
GeneID
11069
Background
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of postsynapse organization. Predicted to act upstream of or within with a positive effect on hormone secretion. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in membrane. Predicted to be active in several cellular components, including glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII;

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