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PSMD8


Official Full Name
proteasome 26S subunit, non-ATPase 8
Organism
Homo sapiens
Gene ID
5714
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
Synonyms
S14; p31; HIP6; HYPF; Nin1p; Rpn12; HEL-S-91n

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Cat.No. Product Name Price
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CDFL010974 Mouse Psmd8 cDNA Clone(NM_026545.3) Inquiry
CDFR005375 Rat Psmd8 cDNA Clone(NM_001100831.1) Inquiry
MiUTR1H-08392 PSMD8 miRNA 3'UTR clone Inquiry
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CDCH069166 human PSMD8 ORF clone (NM_002812.4) Inquiry
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