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PSEN1


Official Full Name
presenilin 1
Organism
Homo sapiens
Gene ID
5663
Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Synonyms
AD3; FAD; PS1; PS-1; S182; CMD1U; PSNL1; ACNINV3

Cat.No. Product Name Price
SHR145878 shRNA set against Mouse Psen1(NM_008943.2) Inquiry
SHH384860 shRNA set against Human PSEN1 (NM_000021.3) Inquiry
SHH384864 shRNA set against Mouse PSEN1 (NM_008943.2) Inquiry
SHH384868 shRNA set against Rat PSEN1 (NM_019163.3) Inquiry
SHR146172 shRNA set against Rat Psen1(NM_019163.3) Inquiry
SHW004681 shRNA set against Chicken PSEN1 (NM_204163) Inquiry
SHW014539 shRNA set against Danio rerio PSEN1 (NM_131024) Inquiry
Cat.No. Product Name Price
CDFH015310 Human PSEN1 cDNA Clone(NM_007318.2) Inquiry
CDFR011461 Rat Psen1 cDNA Clone(NM_019163.3) Inquiry
MiUTR1M-09672 PSEN1 miRNA 3'UTR clone Inquiry
MiUTR1R-06129 PSEN1 miRNA 3'UTR clone Inquiry
SKO0715 PSEN1 Validated sgRNA vector Inquiry
SKO0920 PSEN1 Validated sgRNA vector Inquiry
CDCB166156 Chicken PSEN1 ORF Clone (NM_204163) Inquiry
CDCB176014 Danio rerio PSEN1 ORF Clone (NM_131024) Inquiry
CDCB180992 Rabbit PSEN1 ORF clone (XM_002719669.2) Inquiry
CDCH068820 human PSEN1 ORF clone (NM_007318.2) Inquiry
CDCH068824 Mouse Psen1 ORF clone (NM_008943.2) Inquiry
CDCR378504 Rat Psen1 ORF Clone(NM_019163.3) Inquiry
CDCS405359 Human PSEN1 ORF Clone (BC011729) Inquiry
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