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PPP1R15B


Official Full Name
protein phosphatase 1 regulatory subunit 15B
Organism
Homo sapiens
Gene ID
84919
Background
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
Synonyms
CREP; MSSGM2

Cat.No. Product Name Price
SHH381124 shRNA set against Human PPP1R15B (NM_032833.3) Inquiry
SHH381132 shRNA set against Rat PPP1R15B (NM_001107175.1) Inquiry
SHH381128 shRNA set against Mouse PPP1R15B (NM_133819.3) Inquiry
SHW010123 shRNA set against Danio rerio PPP1R15B (NM_001045219) Inquiry
Cat.No. Product Name Price
CDFL010666 Mouse Ppp1r15b cDNA Clone(NM_133819.3) Inquiry
CDFR006851 Rat Ppp1r15b cDNA Clone(NM_001107175.1) Inquiry
SKO0965 PPP1R15B Validated sgRNA vector Inquiry
CDCB171598 Danio rerio PPP1R15B ORF Clone (NM_001045219) Inquiry
CDCB183249 Rabbit PPP1R15B ORF clone (XM_008268536.1) Inquiry
CDCH394980 Human PPP1R15B ORF clone(NM_032833.3) Inquiry
CDCR265505 Mouse Ppp1r15b ORF Clone(NM_133819.3) Inquiry
CDCR373900 Rat Ppp1r15b ORF Clone(NM_001107175.1) Inquiry
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