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PPM1D


Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1D
Organism
Homo sapiens
Gene ID
8493
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Synonyms
JDVS; WIP1; IDDGIP; PP2C-DELTA

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SHH380808 shRNA set against Human PPM1D (NM_003620.3) Inquiry
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CDCS411378 Human PPM1D ORF Clone (BC016480) Inquiry
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