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PPM1B

Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1B
Organism
Homo sapiens
GeneID
5495
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Synonyms
PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X;

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