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PFKFB4


Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Organism
Homo sapiens
Gene ID
5210
Background
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Cat.No. Product Name Price
SHH373944 shRNA set against Human PFKFB4 (NM_004567.2) Inquiry
SHH373952 shRNA set against Rat PFKFB4 (NM_019333.1) Inquiry
SHR107644 shRNA set against Rat Pfkfb4(NM_019333.1) Inquiry
SHR107718 shRNA set against Human PFKFB4(NM_004567.2) Inquiry
SHW001239 shRNA set against Chicken PFKFB4 (NM_001030584) Inquiry
SHW009391 shRNA set against Danio rerio PFKFB4 (NM_001037377) Inquiry
Cat.No. Product Name Price
CDFH014122 Human PFKFB4 cDNA Clone(NM_004567.2) Inquiry
CDFH014123 Human PFKFB4 cDNA Clone(NM_004567.2) Inquiry
CDFR011420 Rat Pfkfb4 cDNA Clone(NM_019333.1) Inquiry
MiUTR1H-07803 PFKFB4 miRNA 3'UTR clone Inquiry
MiUTR1R-05779 PFKFB4 miRNA 3'UTR clone Inquiry
CDCB162714 Chicken PFKFB4 ORF Clone (NM_001030584) Inquiry
CDCB170866 Danio rerio PFKFB4 ORF Clone (NM_001037377) Inquiry
CDCB190632 Rabbit PFKFB4 ORF clone (XM_008260608.1) Inquiry
CDCL185693 Human PFKFB4 ORF clone(NM_004567.2) Inquiry
CDCR378622 Rat Pfkfb4 ORF Clone(NM_019333.1) Inquiry
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