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PFKFB3


Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Organism
Homo sapiens
Gene ID
5209
Background
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Synonyms
PFK2; IPFK2; iPFK-2

Cat.No. Product Name Price
SHH373932 shRNA set against Human PFKFB3 (NM_004566.3) Inquiry
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SHR107966 shRNA set against Rat Pfkfb3(NM_057135.1) Inquiry
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CDCB187577 Rabbit PFKFB3 ORF clone (XM_008248588.1) Inquiry
CDCL148283 Human PFKFB3 ORF clone (NM_001145443.1) Inquiry
CDCR380776 Rat Pfkfb3 ORF Clone(NM_057135.1) Inquiry
CDCS408517 Human PFKFB3 ORF Clone (BC040482) Inquiry
Cat.No. Product Name Price
CC-1050 PFKFB3 Easy KO Kit Inquiry
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