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PCSK1


Official Full Name
proprotein convertase subtilisin/kexin type 1
Organism
Homo sapiens
Gene ID
5122
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]
Synonyms
PC1; PC3; NEC1; SPC3; PC1/3; BMIQ12

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Cat.No. Product Name Price
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CDFH013857 Human PCSK1 cDNA Clone(NM_001177876.1) Inquiry
CDFH013858 Human PCSK1 cDNA Clone(NM_001177875.1) Inquiry
CDFR011157 Rat Pcsk1 cDNA Clone(NM_017091.2) Inquiry
MiUTR1M-09016 PCSK1 miRNA 3'UTR clone Inquiry
MiUTR1R-05687 PCSK1 miRNA 3'UTR clone Inquiry
MiUTR4H-TG06533 PCSK1 miRNA 3'UTR clone Inquiry
CDCB174583 Danio rerio PCSK1 ORF Clone (NM_001137662) Inquiry
CDCB190521 Rabbit PCSK1 ORF clone (XM_008261964.1) Inquiry
CDCL147049 Mouse PCSK1 ORF clone (NM_001177875.1) Inquiry
CDCL185638 Human PCSK1 ORF clone(NM_000439.4) Inquiry
CDCL185639 Mouse PCSK1 ORF clone(NM_013628.2) Inquiry
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