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PAX6


Official Full Name
paired box 6
Organism
Homo sapiens
Gene ID
5080
Background
This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]
Synonyms
AN; AN1; AN2; FVH1; MGDA; WAGR; ASGD5; D11S812E

Cat.No. Product Name Price
SHH371168 shRNA set against Rat PAX6 (NM_013001.2) Inquiry
SHW005566 shRNA set against Chicken PAX6 (NM_205066) Inquiry
SHH371160 shRNA set against Human PAX6 (NM_000280.4) Inquiry
SHH371164 shRNA set against Mouse PAX6 (NM_013627.5) Inquiry
SHR089698 shRNA set against Rat Pax6(NM_013001.2) Inquiry
Cat.No. Product Name Price
CDCH017288 Mouse PAX6 ORF clone(NM_001244200.1) Inquiry
CDFH013757 Human PAX6 cDNA Clone(NM_001127612.1) Inquiry
CDFR010808 Rat Pax6 cDNA Clone(NM_013001.2) Inquiry
MiUTR1R-05636 PAX6 miRNA 3'UTR clone Inquiry
CDCB160307 Human PAX6 ORF clone (NM_001604) Inquiry
CDCB167041 Chicken PAX6 ORF Clone (NM_205066) Inquiry
CDCB180794 Rabbit PAX6 ORF clone (NM_001082217.1) Inquiry
CDCH017285 Mouse PAX6 ORF clone(NM_001244198.1) Inquiry
CDCH017296 Mouse PAX6 ORF clone(NM_001244201.1) Inquiry
CDCR252010 Mouse Pax6 ORF Clone(NM_013627.5) Inquiry
CDCR348759 Human PAX6 ORF Clone(NM_001127612.1) Inquiry
CDCR377885 Rat Pax6 ORF Clone(NM_013001.2) Inquiry
CDCS405544 Human PAX6 ORF Clone (BC011953) Inquiry
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