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pax6a


Official Full Name
paired box 6a
Organism
Danio rerio
Gene ID
30567
Background
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of cell population proliferation; retinal cone cell differentiation; and retinal rod cell differentiation. Acts upstream of or within several processes, including brain development; neural crest cell migration; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including immature eye; nervous system; neural keel; neural plate; and neural rod. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
pax6; cb280; pax-a; Pax6.1; paxzfa; PAXZF-A; fc20e07; zfpax-6a; zfpax-6b; pax[zf-a]; wu:fc20e07

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