PAQR7

Official Full Name

progestin and adipoQ receptor family member 7

Organism

Homo sapiens

GeneID

164091

Background

Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

mSR; MPRA; PGLP;

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Detailed Information

PAQR7 works as an intermediary mediating nongenomic progesterone action in female reproductive tissue

As an indispensable member of membrane progestin receptors in the progestin and adipoQ receptor (PAQR) family, Progestin and adipoQ receptor 7 (PAQR7) is responsible initiation of nongenomic progesterone actions at the cell surface. Even though it is belonging to the family, it contains no structural or sequence homology to nPR. Firstly, cloned and sequenced from spotted seatrout ovaries, the PAQR7 gene encodes a protein composed of 352 amino acids with a mass of approximately 40 kDa in spotted seatrouts. The distribution of PAQR7 has been demonstrated that mainly focused 0n the reproductive tissues, including ovary and testis. More than this, PAQR7 has been confirmed to have some linkages with progestin-induced sperm hypermotility. In the female reproductive tissue, PAQR7 plays a significant role in regulating a series of progestin-induced effects, including oocyte maturation induced by progestin, ovarian follicles growth and onset of parturition. More than this, PAQR7 also has some associations with several female reproductive diseases.

PAQR7 works as a receptor for the progesterone to induce relaxation of human umbilical cord vascular smooth muscle cells

The matter of how progesterone functions on the vascular smooth muscle cell (VSMC) relaxation is investigated in cultured human umbilical vein VSMCs. High expression of membrane progesterone receptors mPRα, mPRβ, and mPRγ can be found in VSMCs while nuclear progesterone receptor (nPR) is the opposite situation. In a VSMC collagen gel disk contraction assay and an endothelium-denuded human umbilical artery ring tension assay, Progesterone and mPR-selective agonist, but not nPR agonist can induce muscle relaxation. The effect induced by progesterone and mPR-selective agonist of ERK and Akt phosphorylation increase and cAMP levels decrease can be blocked by the preincubation with pertussis toxin.

As members of the progesterone AdipoQ Receptor family (PAQR), the membrane progesterone receptors (mPRs) have been confirmed to be involved in nongenomic actions and functions of progesterone in a wide variety of cell types since their discovery. The mPRalpha subtype, PAQR7 has been identified as an intermediary for progesterone to exert its protections onto the human umbilical vein endothelial cells (HUVECs). On the cell membranes of HUVECs, the progesterone rapidly activates an inhibitory G protein and several intracellular signaling pathways by PAQR7 receptor, through which upregulate NO production in these cells.

membrane progestin receptor alpha Figure 1. Involvement of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation. (Yefei Pang, et al. 2020)

References:

Pang Y, Thomas P. Involvement of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation. American Journal of Physiology-Endocrinology and Metabolism, 2021, 320(3): E453-E466.
Pang Y, Thomas P. Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPRα (PAQR7). Molecular and cellular endocrinology, 2018, 474: 20-34.

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