Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC011298 | Panoply™ Human PAQR7 Knockdown Stable Cell Line | Inquiry |
| CSC-SC011298 | Panoply™ Human PAQR7 Over-expressing Stable Cell Line | Inquiry |
| CSC-SC011298-1 | Human PAQR7 Stable Cell Line - HEK293 | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD11806Z | Human PAQR7 adenoviral particles | Inquiry |
| LV20969L | human PAQR7 (NM_178422) lentivirus particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHH365040 | shRNA set against Rat Olr50 (NM_001000131.1) | Inquiry |
| SHH370620 | shRNA set against Human PAQR7 (NM_178422.5) | Inquiry |
| SHH370624 | shRNA set against Mouse PAQR7 (NM_027995.2) | Inquiry |
| SHH370628 | shRNA set against Rat PAQR7 (NM_001034081.1) | Inquiry |
| SHR087774 | shRNA set against Rat Paqr7(NM_001034081.1) | Inquiry |
| SHR087792 | shRNA set against Mouse Paqr7(NM_027995.2) | Inquiry |
| SHW002936 | shRNA set against Chicken PAQR7 (NM_001163651) | Inquiry |
| SHW015591 | shRNA set against Danio rerio PAQR7B (NM_183345) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| CDFR000129 | Rat Olr50 cDNA Clone(NM_001000131.1) | Inquiry |
| CDFR004343 | Rat Paqr7 cDNA Clone(NM_001034081.1) | Inquiry |
| MiUTR1M-08896 | PAQR7 miRNA 3'UTR clone | Inquiry |
| MiUTR1R-05183 | OLR50 miRNA 3'UTR clone | Inquiry |
| MiUTR1R-05621 | PAQR7 miRNA 3'UTR clone | Inquiry |
| MiUTR4H-TG06416 | PAQR7 miRNA 3'UTR clone | Inquiry |
| CDCB164411 | Chicken PAQR7 ORF Clone (NM_001163651) | Inquiry |
| CDCB177066 | Danio rerio PAQR7B ORF Clone (NM_183345) | Inquiry |
| CDCB194082 | Rabbit PAQR7 ORF clone (XM_008265922.1) | Inquiry |
| CDCR367206 | Rat Olr50 ORF Clone(NM_001000131.1) | Inquiry |
| CDCR371373 | Rat Paqr7 ORF Clone(NM_001034081.1) | Inquiry |
| CDCS417590 | Human PAQR7 ORF Clone (BC034015) | Inquiry |
As an indispensable member of membrane progestin receptors in the progestin and adipoQ receptor (PAQR) family, Progestin and adipoQ receptor 7 (PAQR7) is responsible initiation of nongenomic progesterone actions at the cell surface. Even though it is belonging to the family, it contains no structural or sequence homology to nPR. Firstly, cloned and sequenced from spotted seatrout ovaries, the PAQR7 gene encodes a protein composed of 352 amino acids with a mass of approximately 40 kDa in spotted seatrouts. The distribution of PAQR7 has been demonstrated that mainly focused 0n the reproductive tissues, including ovary and testis. More than this, PAQR7 has been confirmed to have some linkages with progestin-induced sperm hypermotility. In the female reproductive tissue, PAQR7 plays a significant role in regulating a series of progestin-induced effects, including oocyte maturation induced by progestin, ovarian follicles growth and onset of parturition. More than this, PAQR7 also has some associations with several female reproductive diseases.
The matter of how progesterone functions on the vascular smooth muscle cell (VSMC) relaxation is investigated in cultured human umbilical vein VSMCs. High expression of membrane progesterone receptors mPRα, mPRβ, and mPRγ can be found in VSMCs while nuclear progesterone receptor (nPR) is the opposite situation. In a VSMC collagen gel disk contraction assay and an endothelium-denuded human umbilical artery ring tension assay, Progesterone and mPR-selective agonist, but not nPR agonist can induce muscle relaxation. The effect induced by progesterone and mPR-selective agonist of ERK and Akt phosphorylation increase and cAMP levels decrease can be blocked by the preincubation with pertussis toxin.
As members of the progesterone AdipoQ Receptor family (PAQR), the membrane progesterone receptors (mPRs) have been confirmed to be involved in nongenomic actions and functions of progesterone in a wide variety of cell types since their discovery. The mPRalpha subtype, PAQR7 has been identified as an intermediary for progesterone to exert its protections onto the human umbilical vein endothelial cells (HUVECs). On the cell membranes of HUVECs, the progesterone rapidly activates an inhibitory G protein and several intracellular signaling pathways by PAQR7 receptor, through which upregulate NO production in these cells.
Figure 1. Involvement of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation. (Yefei Pang, et al. 2020)
References: