PAIP1

Official Full Name

poly(A) binding protein interacting protein 1

Organism

Homo sapiens

GeneID

10605

Background

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

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Detailed Information

PAIP1 in cervical cancer and promoted cervical carcinogenesis

Encoded by PAIP1, the 479-residue poly(A)-binding protein interacting protein (Paip1) was involved in initiation of translation in eukaryotes by binding polyadenylate-binding protein cytoplasmic 1 and several eukaryotic initiation factors 4F complexes. For its stimuli in translation rates implicated in several pathogenic roles, may be account of its two displayed domain PAM1 and PAM2, of which PAM1 is RRM1 and 2 domains of the poly Adenylate Binding Protein (PABP) interacted and PAM2 is C-terminal domain of PABP. Its interaction with elF3 is S6 kinase regulated. All those interactions facilitate circularization of the RNA and translation initiation. More than this, up-regulation of Paip1 was found in invasive CCs, where Paip1 also played a role in DNA repair and cell cycle regulation. And over-expression of Paip1 was also reported in breast cancer, it is closely related to cell cycle and poor prognosis. All those gave the indication that Paip1 might role as a new target in an effective anti-tumor therapy strategy.

PAIP1 in oral squamous cell carcinoma

The frequent occurrence of short arm amplification of chromosome 5 and identification of PAIP1 as a target gene in 5p gain in cervical cancer have led to the hypothesis that there is an undergoing amplification of PAIP1 in head and neck cancer. In consistent with this, strong correlation between the PAIP1 copy number and mRNA levels genetic alterations of mutation and fusion amplifications were seen from head and neck cancers. So those results may indicate that PAIP1 copy number level amplification is associated with PAIP1 mRNA transcript level increase in cancer cells. Publicly available data derived from the Gene Expression Omnibus (GEO), The cancer Genome Altas (TCGA), and Clinical Proteomic Tumor Analysis Consortium (CPTAC), was used to analyze PAIP1 expression in oral cancer, the result suggested that PAIP1 mRNA and protein levels were increased in oral squamous cell carcinoma (OSCC). More than this, in samples of advanced stage or with worse pattern of invasion, the high PAIP1 expression was more evident. PAIP1 knockdown in vitro experiments has also been confirmed to lead to colony forming and OSCC cell lines aggressiveness attenuation.

Figure 1. Model of Paip1 enhancement of translation. (Li N, et al. 2019)

References:

Li N, Piao J, Wang X, et al. Paip1 indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis. Cancer research and treatment: official journal of Korean Cancer Association, 2019, 51(4): 1653.
Swarup N, Hong K O, Chawla K, et al. Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma. International Journal of Oral Science, 2022, 14(1): 1-10.

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