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NR0B2


Official Full Name
nuclear receptor subfamily 0 group B member 2
Organism
Homo sapiens
Gene ID
8431
Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
Synonyms
SHP; SHP1

Cat.No. Product Name Price
SHH354624 shRNA set against Human NR0B2 (NM_021969.2) Inquiry
SHH354628 shRNA set against Mouse NR0B2 (NM_011850.2) Inquiry
SHR019224 shRNA set against Rat Nr0b2(NM_057133.1) Inquiry
SHR019748 shRNA set against Mouse Nr0b2(NM_011850.2) Inquiry
SHW001524 shRNA set against Chicken NR0B2 (NM_001030893) Inquiry
Cat.No. Product Name Price
CDCR380775 Rat Nr0b2 ORF Clone(NM_057133.1) Inquiry
CDFR013742 Rat Nr0b2 cDNA Clone(NM_057133.1) Inquiry
MiUTR1M-07798 NR0B2 miRNA 3'UTR clone Inquiry
CDCB159442 Human NR0B2 ORF clone (BC030207) Inquiry
CDCB162999 Chicken NR0B2 ORF Clone (NM_001030893) Inquiry
CDCB183305 Rabbit NR0B2 ORF clone (XM_002716097.2) Inquiry
CDCL185517 Mouse NR0B2 ORF clone(NM_011850.2) Inquiry
CDCS415397 Human NR0B2 ORF Clone (BC030207) Inquiry
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