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NOTCH2


Official Full Name
notch receptor 2
Organism
Homo sapiens
Gene ID
4853
Background
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Synonyms
hN2; AGS2; HJCYS

Cat.No. Product Name Price
SHR008574 shRNA set against Rat Notch2(NM_024358.1) Inquiry
SHR008592 shRNA set against Mouse Notch2(NM_010928.2) Inquiry
SHH353832 shRNA set against Mouse NOTCH2 (NM_010928.2) Inquiry
SHH353836 shRNA set against Rat NOTCH2 (NM_024358.1) Inquiry
SHW003476 shRNA set against Chicken NOTCH2 (NM_001252033) Inquiry
SHW012420 shRNA set against Danio rerio NOTCH2 (NM_001115094) Inquiry
Cat.No. Product Name Price
CDCB191439 Rabbit NOTCH2 ORF clone (XM_008265576.1) Inquiry
CDCL139205 Mouse Notch2 ORF clone (NM_010928.2) Inquiry
CDFL008472 Mouse Notch2 cDNA Clone(NM_010928.2) Inquiry
CDFR012303 Rat Notch2 cDNA Clone(NM_024358.1) Inquiry
MiUTR1M-07749 NOTCH2 miRNA 3'UTR clone Inquiry
MiUTR1R-04238 NOTCH2 miRNA 3'UTR clone Inquiry
MiUTR4H-TG11861 NOTCH2 miRNA 3'UTR clone Inquiry
SKO0636 NOTCH2 Validated sgRNA vector Inquiry
CDCB164951 Chicken NOTCH2 ORF Clone (NM_001252033) Inquiry
CDCB173895 Danio rerio NOTCH2 ORF Clone (NM_001115094) Inquiry
CDCL139201 Human NOTCH2 ORF clone (NM_001200001.1) Inquiry
Cat.No. Product Name Price
CC-958 NOTCH2 Easy KO Kit Inquiry
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