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NCF4


Official Full Name
neutrophil cytosolic factor 4
Organism
Homo sapiens
Gene ID
4689
Background
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Synonyms
NCF; CGD3; P40PHOX; SH3PXD4

Cat.No. Product Name Price
SHH349956 shRNA set against Human NCF4 (NM_000631.4) Inquiry
SHH349960 shRNA set against Mouse NCF4 (NM_008677.2) Inquiry
SHH349964 shRNA set against Rat NCF4 (NM_001127304.1) Inquiry
SHR000510 shRNA set against Human NCF4(NM_000631.4) Inquiry
SHR000546 shRNA set against Human NCF4(NM_013416.3) Inquiry
SHW002278 shRNA set against Chicken NCF4 (NM_001039272) Inquiry
SHW017618 shRNA set against Danio rerio NCF4 (NM_205711) Inquiry
Cat.No. Product Name Price
CDCB179093 Danio rerio NCF4 ORF Clone (NM_205711) Inquiry
CDFR009524 Rat Ncf4 cDNA Clone(NM_001127304.1) Inquiry
MiUTR1H-06673 NCF4 miRNA 3'UTR clone Inquiry
MiUTR1H-06674 NCF4 miRNA 3'UTR clone Inquiry
CDCB158065 Human NCF4 ORF clone (BC002798) Inquiry
CDCB163753 Chicken NCF4 ORF Clone (NM_001039272) Inquiry
CDCB181175 Rabbit NCF4 ORF clone (NM_001082654.1) Inquiry
CDCH391445 Mouse NCF4 ORF clone(NM_008677.2) Inquiry
CDCL136853 Mouse NCF4 ORF clone (NM_013416.3) Inquiry
CDCR376575 Rat Ncf4 ORF Clone(NM_001127304.1) Inquiry
CDCS405805 Human NCF4 ORF Clone (BC002798) Inquiry
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