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NARF


Official Full Name
nuclear prelamin A recognition factor
Organism
Homo sapiens
Gene ID
26502
Background
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Synonyms
IOP2

Cat.No. Product Name Price
SHH216011 shRNA set against Human NARF(NM_001083608.1) Inquiry
SHH216023 shRNA set against Human NARF(NM_001038618.2) Inquiry
SHH216025 shRNA set against Human NARF(NM_001083608.1) Inquiry
SHH216031 shRNA set against Human NARF(NM_031968.2) Inquiry
SHH216049 shRNA set against Rat Narf(NM_001039207.2) Inquiry
SHH216067 shRNA set against Mouse Narf(NM_026272.3) Inquiry
SHH216085 shRNA set against Human NARF(NM_012336.3) Inquiry
SHH216103 shRNA set against Human NARF(NM_001038618.2) Inquiry
SHH349360 shRNA set against Human NARF (NM_012336.3) Inquiry
SHH349364 shRNA set against Mouse NARF (NM_026272.3) Inquiry
SHH349368 shRNA set against Rat NARF (NM_001039207.2) Inquiry
SHW006377 shRNA set against Danio rerio NARF (NM_001002342) Inquiry
Cat.No. Product Name Price
CDFG005602 Human NARF cDNA Clone(NM_031968.2) Inquiry
MiUTR1M-07499 NARF miRNA 3'UTR clone Inquiry
MiUTR1H-06637 NARF miRNA 3'UTR clone Inquiry
MiUTR1H-06636 NARF miRNA 3'UTR clone Inquiry
MiUTR1H-06635 NARF miRNA 3'UTR clone Inquiry
CDFR004689 Rat Narf cDNA Clone(NM_001039207.2) Inquiry
CDFH012157 Human NARF cDNA Clone(NM_001083608.1) Inquiry
MiUTR1R-04117 NARF miRNA 3'UTR clone Inquiry
MiUTR3H-07599 NARF miRNA 3'UTR clone Inquiry
CDCR371732 Rat Narf ORF Clone(NM_001039207.2) Inquiry
CDCR311513 Human NARF ORF Clone(NM_031968.2) Inquiry
CDCS406924 Human NARF ORF Clone (BC016440) Inquiry
CDCL136529 Human NARF ORF clone (NM_001083608.1) Inquiry
CDCL136527 Human NARF ORF clone (NM_001038618.2) Inquiry
CDCB191311 Rabbit NARF ORF clone (XM_008251175.1) Inquiry
CDCS406925 Human NARF ORF Clone (BC000438) Inquiry
CDCB167852 Danio rerio NARF ORF Clone (NM_001002342) Inquiry
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