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MED12


Official Full Name
mediator complex subunit 12
Organism
Homo sapiens
Gene ID
9968
Background
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
Synonyms
Kto; OKS; FGS1; HDKR; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230

Cat.No. Product Name Price
SHH339859 shRNA set against Human MED12 (NM_005120.2) Inquiry
SHH183377 shRNA set against Mouse Med12(NM_021521.2) Inquiry
SHH183395 shRNA set against Human MED12(NM_005120.2) Inquiry
SHH339863 shRNA set against Mouse MED12 (NM_021521.2) Inquiry
SHH339867 shRNA set against Rat MED12 (NM_001193292.1) Inquiry
SHW009504 shRNA set against Danio rerio MED12 (NM_001039461) Inquiry
Cat.No. Product Name Price
CDCR255458 Mouse Med12 ORF Clone(NM_021521.2) Inquiry
CDFL007495 Mouse Med12 cDNA Clone(NM_021521.2) Inquiry
MiUTR1H-06188 MED12 miRNA 3'UTR clone Inquiry
MiUTR1M-07034 MED12 miRNA 3'UTR clone Inquiry
CDCB170979 Danio rerio MED12 ORF Clone (NM_001039461) Inquiry
CDCB187370 Rabbit MED12 ORF clone (XM_002720091.2) Inquiry
CDCL131635 Human MED12 ORF clone (NM_005120.2) Inquiry
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