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MAML2


Official Full Name
mastermind like transcriptional coactivator 2
Organism
Homo sapiens
Gene ID
84441
Background
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Synonyms
MAM2; MAM3; MAM-3; MLL-MAML2

Cat.No. Product Name Price
SHH337199 shRNA set against Human MAML2 (NM_032427.1) Inquiry
SHH337203 shRNA set against Mouse MAML2 (NM_001013813.3) Inquiry
Cat.No. Product Name Price
CDFG006051 Human MAML2 cDNA Clone(NM_032427.1) Inquiry
CDFG006052 Human MAML2 cDNA Clone(NM_032427.1) Inquiry
CDFG017333 Mouse Maml2 cDNA Clone(NM_001013813.3) Inquiry
CDFL007318 Mouse Maml2 cDNA Clone(NM_173776.3) Inquiry
MiUTR1H-06031 MAML2 miRNA 3'UTR clone Inquiry
CDCB190394 Rabbit MAML2 ORF clone (XM_002708435.2) Inquiry
CDCL129981 Human MAML2 ORF clone (NM_032427.1) Inquiry
CDCL129985 Mouse Maml2 ORF clone (NM_173776.3) Inquiry
CDCL219579 Mouse Maml2 ORF Clone(NM_001013813.3) Inquiry
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