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MTPN

Official Full Name
myotrophin
Background
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3 end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Synonyms
MTPN; myotrophin; GCDP; granule cell differentiation protein; V 1; FLJ31098; FLJ99857; MTPN_HUMAN; Protein V 1; Protein V-1; V-1; V1 protein homologue; zgc:64078; wu:fa10f07

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