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KLHL3


Official Full Name
kelch like family member 3
Organism
Homo sapiens
Gene ID
26249
Background
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Synonyms
PHA2D

Cat.No. Product Name Price
SHH326255 shRNA set against Human KLHL3 (NM_017415.2) Inquiry
Cat.No. Product Name Price
CDFG021662 Mouse Klhl3 cDNA Clone(NM_001195075.1) Inquiry
MiUTR1H-05377 KLHL3 miRNA 3'UTR clone Inquiry
CDCB191742 Rabbit KLHL3 ORF clone (XM_008255055.1) Inquiry
CDCL124873 Mouse KLHL3 ORF clone (NM_017415.2) Inquiry
CDCL124875 Human KLHL3 ORF clone (NM_001257194.1) Inquiry
CDCL124877 Mouse KLHL3 ORF clone (NM_001257195.1) Inquiry
CDCL151242 Mouse Klhl3 ORF clone (NM_001195075.1) Inquiry
CDCS410149 Human KLHL3 ORF Clone (BC034035) Inquiry
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