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IMPA1


Official Full Name
inositol monophosphatase 1
Organism
Homo sapiens
Gene ID
3612
Background
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Synonyms
IMP; IMPA; MRT59

Cat.No. Product Name Price
SHH319301 shRNA set against Human IMPA1 (NM_005536.3) Inquiry
SHH319305 shRNA set against Mouse IMPA1 (NM_018864.5) Inquiry
SHH319309 shRNA set against Rat IMPA1 (NM_032057.1) Inquiry
SHL176930 shRNA set against Rat Impa1(NM_032057.1) Inquiry
SHW006727 shRNA set against Danio rerio IMPA1 (NM_001002745) Inquiry
Cat.No. Product Name Price
CDFH009231 Human IMPA1 cDNA Clone(NM_001144879.1) Inquiry
CDFH009232 Human IMPA1 cDNA Clone(NM_001144878.1) Inquiry
CDFR012995 Rat Impa1 cDNA Clone(NM_032057.1) Inquiry
MiUTR1R-02665 IMPA1 miRNA 3'UTR clone Inquiry
CDCB168202 Danio rerio IMPA1 ORF Clone (NM_001002745) Inquiry
CDCB189747 Rabbit IMPA1 ORF clone (XM_002710658.2) Inquiry
CDCR380009 Rat Impa1 ORF Clone(NM_032057.1) Inquiry
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