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ILK

Official Full Name
integrin linked kinase
Organism
Homo sapiens
GeneID
3611
Background
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Synonyms
P59; ILK-1; ILK-2; p59ILK; HEL-S-28;

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