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IL4R


Official Full Name
interleukin 4 receptor
Organism
Homo sapiens
Gene ID
3566
Background
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Synonyms
CD124; IL4RA; IL-4RA

Cat.No. Product Name Price
SHH319001 shRNA set against Human IL4R (NM_000418.3) Inquiry
SHH319005 shRNA set against Mouse IL4R (NM_001008700.3) Inquiry
SHH319009 shRNA set against Rat IL4R (NM_133380.2) Inquiry
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MiUTR3H-01243 IL4R miRNA 3'UTR clone Inquiry
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CDCL120657 Human IL4R ORF clone (NM_001257407.1) Inquiry
CDCL120659 Mouse IL4R ORF clone (NM_001257997.1) Inquiry
CDCL184893 Rat IL4R ORF clone(NM_133380.2) Inquiry
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