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IL12B


Official Full Name
interleukin 12B
Organism
Homo sapiens
Gene ID
3593
Background
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Synonyms
CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B

Cat.No. Product Name Price
SHH318189 shRNA set against Human IL12B (NM_002187.2) Inquiry
SHH318193 shRNA set against Mouse IL12B (NM_008352.2) Inquiry
SHH318197 shRNA set against Rat IL12B (NM_022611.1) Inquiry
SHL170766 shRNA set against Rat Il12b(NM_022611.1) Inquiry
SHR085722 shRNA set against Mouse Il12b(NM_008352.2) Inquiry
SHR085740 shRNA set against Human IL12B(NM_002187.2) Inquiry
SHW006067 shRNA set against Chicken IL12B (NM_213571) Inquiry
Cat.No. Product Name Price
CDCL184750 Human IL12B ORF clone(NM_002187.2) Inquiry
CDCL184751 Rat IL12B ORF clone(NM_022611.1) Inquiry
CDFH009139 Human IL12B cDNA Clone(NM_002187.2) Inquiry
CDFL006128 Mouse Il12b cDNA Clone(NM_008352.2) Inquiry
CDFR012044 Rat Il12b cDNA Clone(NM_022611.1) Inquiry
MiUTR1M-05967 IL12B miRNA 3'UTR clone Inquiry
MiUTR1R-02623 IL12B miRNA 3'UTR clone Inquiry
MiUTR4H-TG04483 IL12B miRNA 3'UTR clone Inquiry
CDCB156891 Canine IL12B ORF clone (NM_001003292.1) Inquiry
CDCB167542 Chicken IL12B ORF Clone (NM_213571) Inquiry
CDCB185022 Rabbit IL12B ORF clone (XM_002710347.2) Inquiry
CDCR245328 Mouse Il12b ORF Clone(NM_008352.2) Inquiry
CDCS410670 Human IL12B ORF Clone (BC067499) Inquiry
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