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IKZF1


Official Full Name
IKAROS family zinc finger 1
Organism
Homo sapiens
Gene ID
10320
Background
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Synonyms
IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452

Cat.No. Product Name Price
SHW005588 shRNA set against Chicken IKZF1 (NM_205088) Inquiry
SHH318037 shRNA set against Human IKZF1 (NM_006060.4) Inquiry
SHH318041 shRNA set against Mouse IKZF1 (NM_009578.2) Inquiry
SHH318045 shRNA set against Rat IKZF1 (NM_001107237.1) Inquiry
SHL170270 shRNA set against Mouse Ikzf1(NM_001025597.1) Inquiry
SHL170406 shRNA set against Mouse Ikzf1(NM_009578.2) Inquiry
SHW014508 shRNA set against Danio rerio IKZF1 (NM_130986) Inquiry
Cat.No. Product Name Price
MiUTR4H-TG04460 IKZF1 miRNA 3'UTR clone Inquiry
MiUTR1M-05960 IKZF1 miRNA 3'UTR clone Inquiry
CDFR006961 Rat Ikzf1 cDNA Clone(NM_001107237.1) Inquiry
CDCL120059 Mouse Ikzf1 ORF clone (NM_001025597.1) Inquiry
CDFG017560 Mouse Ikzf1 cDNA Clone(NM_001025597.1) Inquiry
CDCL120069 Human IKZF1 ORF clone (NM_001220768.1) Inquiry
CDCL120071 Human IKZF1 ORF clone (NM_001220769.1) Inquiry
MiUTR1M-05961 IKZF1 miRNA 3'UTR clone Inquiry
CDCS409723 Human IKZF1 ORF Clone (BC018349) Inquiry
CDCR373960 Rat Ikzf1 ORF Clone(NM_001107237.1) Inquiry
CDCR247505 Mouse Ikzf1 ORF Clone(NM_009578.2) Inquiry
CDCL120073 Human IKZF1 ORF clone (NM_001220770.1) Inquiry
CDCL120067 Human IKZF1 ORF clone (NM_001220767.1) Inquiry
CDCL120065 Mouse IKZF1 ORF clone (NM_001220766.1) Inquiry
CDCL120063 Human IKZF1 ORF clone (NM_001220776.1) Inquiry
CDCB184028 Rabbit IKZF1 ORF clone (XM_008248422.1) Inquiry
CDCB175983 Danio rerio IKZF1 ORF Clone (NM_130986) Inquiry
CDCL120075 Human IKZF1 ORF clone (NM_001220771.1) Inquiry
CDCB167063 Chicken IKZF1 ORF Clone (NM_205088) Inquiry
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