IGFBP2

Official Full Name

insulin like growth factor binding protein 2

Organism

Homo sapiens

Gene ID

3485

Background

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Synonyms

IBP2; IGF-BP53

Bio Chemical Class

Insulin-like growth factor binding

Protein Sequence

MLPRVGCPALPLPPPPLLPLLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ

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Cat.No.	Product Name	Price
CSC-DC007485	Panoply™ Human IGFBP2 Knockdown Stable Cell Line	Inquiry
CSC-SC007485	Panoply™ Human IGFBP2 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD07954Z	Human IGFBP2 adenoviral particles	Inquiry
LV15259L	human IGFBP2 (NM_000597) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH317549	shRNA set against Rat IGFBP2 (NM_013122.2)	Inquiry
SHH317541	shRNA set against Human IGFBP2 (NM_000597.2)	Inquiry
SHH317545	shRNA set against Mouse IGFBP2 (NM_008342.3)	Inquiry
SHL168600	shRNA set against Human IGFBP2(NM_000597.2)	Inquiry
SHL168636	shRNA set against Rat Igfbp2(NM_013122.2)	Inquiry
SHW005854	shRNA set against Chicken IGFBP2 (NM_205359)	Inquiry
SHW014912	shRNA set against Danio rerio IGFBP2A (NM_131458)	Inquiry

Cat.No.	Product Name	Price
RP00668	Recombinant Human IGFBP2 (C-His)	Inquiry

Cat.No.	Product Name	Price
CDCR245314	Mouse Igfbp2 ORF Clone(NM_008342.3)	Inquiry
CDFH009064	Human IGFBP2 cDNA Clone(NM_000597.2)	Inquiry
CDFR010921	Rat Igfbp2 cDNA Clone(NM_013122.2)	Inquiry
MiUTR1H-04839	IGFBP2 miRNA 3'UTR clone	Inquiry
MiUTR1R-02602	IGFBP2 miRNA 3'UTR clone	Inquiry
CDCB156565	Cynomolgus IGFBP2 ORF clone	Inquiry
CDCB167329	Chicken IGFBP2 ORF Clone (NM_205359)	Inquiry
CDCB176387	Danio rerio IGFBP2A ORF Clone (NM_131458)	Inquiry
CDCB188652	Rabbit IGFBP2 ORF clone (XM_002712467.2)	Inquiry
CDCR337252	Human IGFBP2 ORF Clone(NM_000597.2)	Inquiry
CDCR377868	Rat Igfbp2 ORF Clone(NM_013122.2)	Inquiry

Detailed Information

Among the IGFBPs family, which major function is modulating the biological functions of IGFs, IGFBP-2 has been received attention from researchers in biological area by the reason that it is involved in many signaling pathways which is implicated with various disease.

IGFBP-2 signaling

Accumulating studies have shown that IGFBP-2 interacts with not only IGFs in the circulation, but also components of the extracellular matrix (ECM), cell surface proteoglycans and integrin receptors. Understanding the complexes signaling pathways of IGFBP-2 will contribute to further studies about its function as a therapeutic target.

A number of studies have found that IGFBP-2 regulate access of IGFs to their receptors with involvement of specific IGFBP-2 protease, which can be activated by factors like hormones, cytokines, drugs and protease inhibitors also. IGFBP/IGF complex is cleaved by proteolysis in most cases, though it might show an acquired resistance to proteolysis. Thus, IGFs work its biological function. This has been usually reported in cancer studies and IGFBP-2 proteolysis might be a reason that makes tumor aggressiveness increase.

In addition, researches also revealed that IGFBP-2 can interact with a number of components of the extracellular matrix and cell membrane such as cell surface proteoglycan receptor (CSPG; RPTPβ) and integrin receptors (aVb3; a5b1), resulting in the activation and modulation of intercellular signaling elements and pathways. Interestingly, those signaling pathways not only regulate several cellular functions, but also the expression and action of IGFBP-2 in turn.

Moreover, it has been reported that IGFBP-2 enters cell by nuclear transportation complexes (importin α and β) and interact with some intracellular specific binders such as cell cycle inhibitor p21 or Pim-1-associated protein-1 (PAP-1)-associated protein-1 (PAPA-1). All these interactions have been demonstrated that involve in IGFBP-2 growth-promoting actions. For example, studies about tumorigenesis have shown that nuclear IGFBP-2 directly or indirectly contributes to the development of a pro-metastatic milieu by enhancing the expression of the angiogenic growth factor VEGF-A, which consistent with the enhancement of an aggressive cancer phenotype.

All cellular signaling pathways are illustrated (Figure 1).

Figure 1. IGFBP-2 cellular activities. (Russo V C, et al.)

Roles of IGFBP-2 in cancer

Previous researches have shown that IGFBP-2 is overexpressed in various tumors such as glioma, prostate cancer, breast cancer, lung cancer, leukemia, colorectal cancer, ovarian cancer, gastric cancer and so on. Furthermore, it has been shown that abnormal overexpression of IGFBP2 is implicated with tumor metastasis. Thus, IGFBP-2 is an important regulator of cell invasion and migration in the context of tumor development. It has been shown that IGFBP-2 works its function by involving in several steps of metastatic process, degrading almost all of the ECM components and activation the expression of VEGF-A during tumorigenesis and tumor progression. Thus, it might have potential clinical applications as a therapeutic target.

In addition to the roles in cancer, IGFBP-2 also plays important roles in metabolism process and other diseases including obesity and diabetes which has been report by a number of researches recently.

References:

Clemmons D. Role of IGF binding proteins in regulating IGF responses to changes in metabolism. Journal of Molecular Endocrinology, 2018, 61(1): JME-18-0016.
Yao X, et al. IGF-binding protein 2 is a candidate target of therapeutic potential in cancer. Tumour Biol, 2016, 37(2):1451-1459.
Russo V C, et al. IGFBP-2: The dark horse in metabolism and cancer. Cytokine & Growth Factor Reviews, 2015, 26(3):329-346.
Zeng L, et al. IGFBP-2/PTEN: A critical interaction for tumours and for general physiology? Journal of the Growth Hormone Research Society & the International Igf Research Society, 2015, 25(3):103.
Spitschak M, et al. Potential Functions of IGFBP-2 for Ovarian Folliculogenesis and Steroidogenesis. Frontiers in Endocrinology, 2018, 9.

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