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HOGA1


Official Full Name
4-hydroxy-2-oxoglutarate aldolase 1
Organism
Homo sapiens
Gene ID
112817
Background
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Synonyms
HP3; NPL2; DHDPS2; DHDPSL; C10orf65

Cat.No. Product Name Price
SHH313941 shRNA set against Human HOGA1 (NM_138413.3) Inquiry
SHH313945 shRNA set against Mouse HOGA1 (NM_026152.1) Inquiry
SHW018017 shRNA set against Danio rerio HOGA1 (NM_212870) Inquiry
Cat.No. Product Name Price
CDCS418709 Human HOGA1 ORF Clone (BC011916) Inquiry
CDFH008704 Human HOGA1 cDNA Clone(NM_001134670.1) Inquiry
CDFR006094 Rat Hoga1 cDNA Clone(NM_001106355.1) Inquiry
MiUTR1M-00010 HOGA1 miRNA 3'UTR clone Inquiry
MiUTR4H-TG02708 HOGA1 miRNA 3'UTR clone Inquiry
CDCB179492 Danio rerio HOGA1 ORF Clone (NM_212870) Inquiry
CDCB191039 Rabbit HOGA1 ORF clone (XM_002718577.2) Inquiry
CDCR006750 Human HOGA1 ORF clone(NM_138413.3) Inquiry
CDCR350080 Human HOGA1 ORF Clone(NM_001134670.1) Inquiry
CDCR373158 Rat Hoga1 ORF Clone(NM_001106355.1) Inquiry
CDCS418710 Human HOGA1 ORF Clone (BC045550) Inquiry
CDCS418711 Human HOGA1 ORF Clone (BC057821) Inquiry
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